Article
Screening for mutations of Bcl10 in leukaemia.
British journal of haematology - 1 Jun 2000
Grimwade D, Du M Q, Langabeer S, Rogers J, Solomon E
Abstract excerpt
The Bcl10 gene was identified through characterization of the t(1;14)(p22;q32) associated with mucosa-associated lymphoid tissue (MALT) lymphoma. Bcl10 is implicated in the regulation of apoptosis and has been reported to be mutated in other subtypes of non-Hodgkin's B-cell lymphoma (B-NHL) and leukaemic cell lines, raising the possibility that its deregulation could be implicated in other forms of haematological...
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