Article
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia - 1 Nov 1998
Zhou M, Gu L, Yeager A M, Findley H W
Abstract excerpt
Fas (APO-1/CD95) is a cell-surface protein that can mediate apoptosis upon specific ligand or antibody binding. The Bcl-2 protein may function as a modulator of Fas-induced apoptosis by blocking a downstream activation step, and Bcl-2 expression in acute lymphoblastic leukemia (ALL) cells appears...
Topics
- Apoptosis
- Caspase 3
- Caspases
- Child
- Enzyme Activation
- Flow Cytometry
- Genes, p53
- Humans
- Hydrolysis
- Mutation
- Phenotype
- Poly(ADP-ribose) Polymerases
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Proto-Oncogene Proteins c-bcl-2
- Tumor Cells, Cultured
- fas Receptor