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Article

Mutant p53 protein, Bcl-2/Bax ratios and apoptosis in paediatric acute lymphoblastic leukaemia.

Journal of cancer research and clinical oncology - 1 Jan 2000

Srinivas G, Kusumakumary P, Nair M K, Panicker K R, Pillai M R

Abstract excerpt

PURPOSE: The Bcl-2 family of proteins regulates a late step in the apoptosis pathway. Bcl-2 protein is believed to be involved in imparting resistance to programmed cell death or apoptosis induced by chemotherapeutic agents and radiation. The anti-apoptotic function of the Bcl-2 protein appears to be modulated by its ability to heterodimerize with other members of the gene family, predominantly Bax, a protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 10641752
DOI: 10.1007/s004320050010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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