Article
Mutation analysis of CD95 (APO-1/Fas) in childhood B-lineage acute lymphoblastic leukaemia.
British journal of haematology - 1 Aug 1998
Beltinger C, Böhler T, Karawajew L, Ludwig W D, Schrappe M, Debatin K M
Abstract excerpt
The CD95 system plays an important role in lymphocyte homeostasis, has been implicated in the development of lymphoid malignancies, exerts a tumour suppressor function, and contributes to drug-induced cytotoxicity. We hypothesized that mutations of CD95 may occur in childhood B-lineage acute lymp...
Topics
- Apoptosis
- Base Sequence
- Burkitt Lymphoma
- Child
- DNA Mutational Analysis
- Genes, bcl-2
- Humans
- Molecular Sequence Data
- Mutation
- Polymorphism, Single-Stranded Conformational
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Promoter Regions, Genetic
- Tumor Cells, Cultured
- fas Receptor