The t(8;21) translocation is not consistently associated with high Bcl-2 expression in de novo acute myeloid leukemias of adults.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The t(8;21) translocation is not consistently associated with high Bcl-2 expression in de novo acute myeloid leukemias of adults.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 1998

Banker D E, Radich J, Becker A, Kerkof K, Norwood T, Willman C, Appelbaum F R

Abstract excerpt

Chromosomal translocations are commonly found in de novo acute myeloid leukemia (AML) cells, and the fusion proteins produced from these genetic abnormalities are assumed to contribute directly to leukemogenesis and/or progression. The AML1/ETO fusion protein, created by translocations between ch...

Topics

Acute Disease
Adolescent
Adult
Aged
Blotting, Western
Bone Marrow
Child
Child, Preschool
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression

Humans

Immunoassay

Leukemia, Myeloid

Leukocytes, Mononuclear

Middle Aged

Mutation

Source

Open in PubMed

Identifiers

PMID: 9865920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9865920-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The t(8;21) translocation is not consistently associated with high Bcl-2 expression in de novo acute myeloid leukemias of adults.PMID 9865920Read ↗

The AML1/ETO fusion protein activates transcription of BCL-2Semantic proximity Read ↗

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.Semantic proximity Read ↗

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced deathSemantic proximity Read ↗

Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcriptsSemantic proximity Read ↗

Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remissionSemantic proximity Read ↗

The Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemia.Semantic proximity Read ↗

Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.Semantic proximity Read ↗

The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETOSemantic proximity Read ↗

C-MYC translocations in de novo B-cell lineage acute leukemias with t(14;18)(cell lines Karpas 231 and 353)Semantic proximity Read ↗

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations.Semantic proximity Read ↗

Incidence of TEL/AML1 Fusion Gene Analyzed Consecutively in Children With Acute Lymphoblastic Leukemia in RelapseSemantic proximity Read ↗

Molecular detection of t(8;21)/AML1‐ETO in AML M1/M2: correlation with cytogenetics, morphology and immunophenotypeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.