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Article

The t(8;21) translocation is not consistently associated with high Bcl-2 expression in de novo acute myeloid leukemias of adults.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 1998

Banker D E, Radich J, Becker A, Kerkof K, Norwood T, Willman C, Appelbaum F R

Abstract excerpt

Chromosomal translocations are commonly found in de novo acute myeloid leukemia (AML) cells, and the fusion proteins produced from these genetic abnormalities are assumed to contribute directly to leukemogenesis and/or progression. The AML1/ETO fusion protein, created by translocations between chromosomes 8 and 21 [t(8;21); G. Nucifora and J. D. Rowley, Leuk. Lymphoma, 14: 353-362, 1994; K. L. Rhoades et al.,...

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PMID: 9865920

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