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Article

Epigenetic silencing and deletion of the BRCA1 gene in sporadic breast cancer.

Breast cancer research : BCR - 1 Jan 2006

Birgisdottir Valgerdur, Stefansson Olafur A, Bodvarsdottir Sigridur K, Hilmarsdottir Holmfridur, Jonasson Jon G, Eyfjord Jorunn E

Abstract excerpt

INTRODUCTION: BRCA1 or BRCA2 germline mutations increase the risk of developing breast cancer. Tumour cells from germline mutation carriers have frequently lost the wild-type allele. This is predicted to result in genomic instability where cell survival depends upon dysfunctional checkpoint mechanisms. Tumorigenic potential could then be acquired through further genomic alterations. Surprisingly, somatic BRCA...

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Source

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Identifiers

PMID: 16846527
DOI: 10.1186/bcr1522
PMCID: PMC1779478

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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