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Article

BRCA1 promoter methylation in sporadic breast tumors: relationship to gene expression profiles.

Breast cancer research and treatment - 1 May 2005

Matros Evan, Wang Zhigang C, Lodeiro Gabriela, Miron Alexander, Iglehart J Dirk, Richardson Andrea L

Abstract excerpt

BRCA1 is a tumor suppressor gene that functions in DNA repair. Basal-like tumors are a distinctive subtype of breast cancer defined by gene expression profiles. Hereditary BRCA1 breast tumors and basal-like sporadic tumors have a similar phenotype and gene expression signature, suggesting involvement of BRCA1 in the pathogenesis of sporadic basal-like cancer. This study evaluates the role of BRCA1 in sporadic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15868446
DOI: 10.1007/s10549-004-7603-8

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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