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Article

BRCA1-methylated sporadic breast cancers are BRCA-like in showing a basal phenotype and absence of ER expression.

Virchows Archiv : an international journal of pathology - 1 Sept 2012

Bal Amanjit, Verma Sangeeta, Joshi Kusum, Singla Anuj, Thakur Ravi, Arora Sunil, Singh Gurpreet

Abstract excerpt

BRCA1 mutations have been associated with hereditary breast cancer only. Recent studies indicate that a subgroup of sporadic breast cancer might also be associated with reduction in BRCA1 mRNA levels and protein expression. However, the mechanism of reduced mRNA and protein expression is yet not fully elucidated. This study aims to assess BRCA1 protein expression and the role of BRCA1 promoter methylation in...

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Source

Identifiers

PMID: 22820987
DOI: 10.1007/s00428-012-1286-z

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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