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Article

BRCA1: the enigma of tissue-specific tumor development.

Trends in genetics : TIG - 1 Jun 2003

Monteiro Alvaro N A

Abstract excerpt

Recent evidence indicates that BRCA1, a gene product associated with breast and ovarian cancer susceptibility, is an important component of the cellular response to DNA damage. Despite being expressed ubiquitously in adult tissues, germline mutations in BRCA1 predispose individuals to breast and ovarian tumors with only minor effects on the predisposition to cancer in other sites. The reason for this tissue...

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Source

Identifiers

PMID: 12801723
DOI: 10.1016/S0168-9525(03)00110-0

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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