Article
Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors.
Genes, chromosomes & cancer - 1 Feb 2011
Joosse Simon A, Brandwijk Kim I M, Mulder Lennart, Wesseling Jelle, Hannemann Juliane, Nederlof Petra M
Abstract excerpt
About 10-20% of all breast carcinomas show a basal-like phenotype, while ∼ 90% of breast tumors from BRCA1-mutation carriers are of this subtype. There is growing evidence that BRCA1-mutated tumors are not just a specific subset of the basal-like tumors, but that (the majority of) basal-like tumors show a dysfunctional BRCA1 pathway. This has major treatment implications, because emerging regimens specifically...
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