Article
Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression.
Nature genetics - 1 Apr 1995
Thompson M E, Jensen R A, Obermiller P S, Page D L, Holt J T
Abstract excerpt
We have characterized expression of the familial breast and ovarian cancer gene, BRCA1, in cases of non-hereditary (sporadic) breast cancer and analyzed the effect of antisense inhibition of BRCA1 on the proliferative rate of mammary epithelial cells. BRCA1 mRNA levels are markedly decreased duri...
Topics
- Alleles
- Base Sequence
- Breast Neoplasms
- Carcinoma in Situ
- Cell Division
- DNA Primers
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Molecular Sequence Data
- Oligonucleotides, Antisense
- Oncogenes
- Polymerase Chain Reaction
- RNA, Messenger
- Tumor Cells, Cultured