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Article

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression.

Nature genetics - 1 Apr 1995

Thompson M E, Jensen R A, Obermiller P S, Page D L, Holt J T

Abstract excerpt

We have characterized expression of the familial breast and ovarian cancer gene, BRCA1, in cases of non-hereditary (sporadic) breast cancer and analyzed the effect of antisense inhibition of BRCA1 on the proliferative rate of mammary epithelial cells. BRCA1 mRNA levels are markedly decreased during the transition from carcinoma in situ to invasive cancer. Experimental inhibition of BRCA1 expression with antisense...

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Identifiers

PMID: 7795653
DOI: 10.1038/ng0495-444

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression.PMID 7795653Read ↗

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