Loss of nuclear BRCA1 expression in breast cancers is associated with a highly proliferative tumor phenotype.

doi:10.1016/s0165-4608(97)00267-7

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Article

Loss of nuclear BRCA1 expression in breast cancers is associated with a highly proliferative tumor phenotype.

Cancer genetics and cytogenetics - 1 Mar 1998

Jarvis E M, Kirk J A, Clarke C L

Abstract excerpt

Recent studies have suggested that BRCA1-associated hereditary breast cancer may be a more aggressive form of disease than sporadic breast cancer. BRCA1-associated breast cancer has been reported to be significantly associated with grade 3 disease. Because grade 3 disease indicates a poor prognos...

Topics

Adult
BRCA1 Protein
Breast Neoplasms
Cell Division
Cell Nucleus
Female
Humans
Immunohistochemistry
Ki-67 Antigen
Middle Aged
Phenotype
Receptors, Estrogen
Receptors, Progesterone

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