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Article

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.

Nature genetics - 1 Nov 1995

Adachi M, Suematsu S, Kondo T, Ogasawara J, Tanaka T, Yoshida N, Nagata S

Abstract excerpt

Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation (lpr) mutation is a leaky mutation in Fas. By means of gene targeting, we generated a mouse strain which is completely deficient in Fas. In addition to the massive production of lymphocytes, the Fas-null mice showed...

Topics

Animals
Apoptosis
Base Sequence
Embryo, Mammalian
Gene Expression Regulation
Gene Targeting
Hyperplasia
Liver
Lymph Nodes
Mice
Mice, Inbred BALB C
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Spleen

Stem Cells

fas Receptor

Source

Identifiers

PMID: 7581453
DOI: 10.1038/ng1195-294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7581453-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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