Article
Transformation of intestinal epithelial cells by chronic TGF-beta1 treatment results in downregulation of the type II TGF-beta receptor and induction of cyclooxygenase-2.
Oncogene - 28 Jan 1999
Sheng H, Shao J, O'Mahony C A, Lamps L, Albo D, Isakson P C, Berger D H, DuBois R N, Beauchamp R D
Abstract excerpt
The precise role of TGF-beta in colorectal carcinogenesis is not clear. The purpose of this study was to determine the phenotypic alterations caused by chronic exposure to TGF-beta in non-transformed intestinal epithelial (RIE-1) cells. Growth of RIE-1 cells was inhibited by >75% following TGF-beta1 treatment for 7 days, after which the cells resumed a normal growth despite the presence of TGF-beta1. These...
Topics
- Animals
- Apoptosis
- Cell Count
- Cell Division
- Cell Transformation, Neoplastic
- Cyclooxygenase 2
- Down-Regulation
- Drug Resistance
- Enzyme Induction
- Epithelial Cells
- Intestines
- Isoenzymes
- Phenotype