Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells.

doi:10.1074/jbc.270.37.22044

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Article

Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells.

The Journal of biological chemistry - 15 Sept 1995

Wang J, Sun L, Myeroff L, Wang X, Gentry L E, Yang J, Liang J, Zborowska E, Markowitz S, Willson J K

Abstract excerpt

Escape from negative growth regulation by transforming growth factor beta (TGF-beta) as a result of the loss of TGF-beta type II receptor (RII) expression has been found to be associated with the replication error (RER) colorectal cancer genotype, which is characteristic of hereditary nonpolyposis colorectal cancers. The RER-positive HCT 116 colon carcinoma cell line was examined for RII mutations. A 1-base...

Topics

Animals
Base Sequence
Cell Line
Clone Cells
Colonic Neoplasms
DNA Primers
Gene Expression
Humans
Mice
Mice, Nude
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Polymerase Chain Reaction

Protein Serine-Threonine Kinases

RNA, Messenger

Receptor, Transforming Growth Factor-beta Type II

Receptors, Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 7665626
DOI: 10.1074/jbc.270.37.22044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7665626-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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