Article
Structural basis of an embryonically lethal single Ala --> Thr mutation in the vnd/NK-2 homeodomain.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 1998
Xiang B, Weiler S, Nirenberg M, Ferretti J A
Abstract excerpt
The structural and DNA binding behavior is described for an analog of the vnd/NK-2 homeodomain, which contains a single amino acid residue alanine to threonine replacement in position 35 of the homeodomain. Multidimensional nuclear magnetic resonance, circular dichroism, and electrophoretic gel r...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Circular Dichroism
- DNA
- Drosophila Proteins
- Drosophila melanogaster
- Genes, Lethal
- Homeodomain Proteins
- Magnetic Resonance Spectroscopy
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Protein Conformation
- Protein Folding
- Temperature
- Transcription Factors