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Article

Structural basis of an embryonically lethal single Ala --> Thr mutation in the vnd/NK-2 homeodomain.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 1998

Xiang B, Weiler S, Nirenberg M, Ferretti J A

Abstract excerpt

The structural and DNA binding behavior is described for an analog of the vnd/NK-2 homeodomain, which contains a single amino acid residue alanine to threonine replacement in position 35 of the homeodomain. Multidimensional nuclear magnetic resonance, circular dichroism, and electrophoretic gel retardation assays were carried out on recombinant 80-aa residue proteins that encompass the wild-type and mutant...

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Identifiers

PMID: 9636163
DOI: 10.1073/pnas.95.13.7412
PMCID: PMC22634

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