Article
Multiple amino acids determine the DNA binding specificity of the Msx-1 homeodomain.
Biochemistry - 30 May 1995
Isaac V E, Sciavolino P, Abate C
Abstract excerpt
This study investigates the sequence features that contribute to the differential DNA binding properties of two divergent homeodomains, Msx-1 and HoxA3. We show that these homeodomains have overlapping, but nonidentical, DNA binding site preferences. We defined the amino acid residues that contri...
Topics
- Amino Acid Sequence
- Amino Acids
- DNA
- Homeodomain Proteins
- MSX1 Transcription Factor
- Molecular Sequence Data
- Mutation
- Protein Binding
- Transcription Factors