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Article

Multiple amino acids determine the DNA binding specificity of the Msx-1 homeodomain.

Biochemistry - 30 May 1995

Isaac V E, Sciavolino P, Abate C

Abstract excerpt

This study investigates the sequence features that contribute to the differential DNA binding properties of two divergent homeodomains, Msx-1 and HoxA3. We show that these homeodomains have overlapping, but nonidentical, DNA binding site preferences. We defined the amino acid residues that contribute to the observed differences in DNA binding specificity by producing a series of mutated polypeptides in which...

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Source

Identifiers

PMID: 7766623
DOI: 10.1021/bi00021a026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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