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Article

Protein--DNA contacts in the structure of a homeodomain--DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

The EMBO journal - 1 Oct 1990

Otting G, Qian Y Q, Billeter M, Müller M, Affolter M, Gehring W J, Wüthrich K

Abstract excerpt

The 1:1 complex of the mutant Antp(C39----S) homeodomain with a 14 bp DNA fragment corresponding to the BS2 binding site was studied by nuclear magnetic resonance (NMR) spectroscopy in aqueous solution. The complex has a molecular weight of 17,800 and its lifetime is long compared with the NMR chemical shift time scale. Investigations of the three-dimensional structure were based on the use of the fully...

Topics

Animals
Base Sequence
DNA
Drosophila
Genes, Homeobox
Genetic Vectors
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Sequence Data
Mutation
Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Oligonucleotide Probes

Protein Conformation

Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1976507
DOI: 10.1002/j.1460-2075.1990.tb07505.x
PMCID: PMC552035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1976507-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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