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Article

The role of loop ZA and Pro371 in the function of yeast Gcn5p bromodomain revealed through molecular dynamics and experiment.

Journal of molecular recognition : JMR - 1 Jan 2000

Pizzitutti Francesco, Giansanti Andrea, Ballario Paola, Ornaghi Prisca, Torreri Paola, Ciccotti Giovanni, Filetici Patrizia

Abstract excerpt

Biological experiments were combined with molecular dynamics simulations to understand the importance of amino acidic residues present in the bromodomain of the yeast histone acetyltransferase Gcn5p. It was found that residue Pro371 plays an important role in the molecular recognition of the acetylated histone H4 tail by Gcn5p bromodomain. Crystallographic analysis of the complex showed that this residue does not...

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PMID: 16180204
DOI: 10.1002/jmr.748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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