Article
Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity.
Structure (London, England : 1993) - 15 Aug 1997
Tucker-Kellogg L, Rould M A, Chambers K A, Ades S E, Sauer R T, Pabo C O
Abstract excerpt
BACKGROUND: The homeodomain is one of the key DNA-binding motifs used in eukaryotic gene regulation, and homeodomain proteins play critical roles in development. The residue at position 50 of many homeodomains appears to determine the differential DNA-binding specificity, helping to distinguish a...
Topics
- Animals
- Asparagine
- Crystallography, X-Ray
- DNA
- Drosophila
- Homeodomain Proteins
- Hydrogen Bonding
- Lysine
- Models, Molecular
- Mutation
- Nucleic Acid Conformation
- Protein Conformation
- Transcription Factors