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Article

Solution structure of the K50 class homeodomain PITX2 bound to DNA and implications for mutations that cause Rieger syndrome.

Biochemistry - 24 May 2005

Chaney Beth A, Clark-Baldwin Kimber, Dave Vrushank, Ma Jun, Rance Mark

Abstract excerpt

We have determined the solution structure of a complex containing the K50 class homeodomain Pituitary homeobox protein 2 (PITX2) bound to its consensus DNA site (TAATCC). Previous studies have suggested that residue 50 is an important determinant of differential DNA-binding specificity among homeodomains. Although structures of several homeodomain-DNA complexes have been determined, this is the first structure of...

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Source

Identifiers

PMID: 15895993
DOI: 10.1021/bi0473253

Genes

PITX2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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