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Article

Structural and biophysical insights into the ligand-free Pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant.

Biochemistry - 17 Jan 2012

Doerdelmann Thomas, Kojetin Douglas J, Baird-Titus Jamie M, Solt Laura A, Burris Thomas P, Rance Mark

Abstract excerpt

The homeodomain-containing transcription factor Pitx2 (pituitary homeobox protein 2) is present in many developing embryonic tissues, including the heart. Its homeodomain is responsible for the recognition and binding to target DNA sequences and thus constitutes a major functional unit in the Pitx2 protein. Nuclear magnetic resonance techniques were employed to determine the solution structure of the native Pitx2...

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Identifiers

PMID: 22224469
DOI: 10.1021/bi201639x
PMCID: PMC3264736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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