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Article

Mutations that affect the ability of the vnd/NK-2 homeoprotein to regulate gene expression: transgenic alterations and tertiary structure.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2003

Koizumi Keita, Lintas Carla, Nirenberg Marshall, Maeng Jin-Soo, Ju Jeong-Ho, Mack James W, Gruschus James M, Odenwald Ward F, Ferretti James A

Abstract excerpt

The importance in downstream target regulation of tertiary structure and DNA binding specificity of the protein encoded by the vndNK-2 homeobox gene is analyzed. The ectopic expression patterns of WT and four mutant vndNK-2 genes are analyzed together with expression of two downstream target genes, ind and msh, which are down-regulated by vndNK-2. Three mutants are deletions of conserved regions (i.e., tinman...

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Share to Amino Acid Substitution
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Gene Expression Regulation, Developmental

Share to Genes, Homeobox

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Source

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Identifiers

PMID: 12626758
DOI: 10.1073/pnas.0438043100
PMCID: PMC152256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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