Article
Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death.
The EMBO journal - 15 Jan 1999
Kissil J L, Cohen O, Raveh T, Kimchi A
Abstract excerpt
A novel approach to the isolation of positive mediators of programmed cell death, based on random inactivation of genes by expression of anti sense RNAs, was employed to identify mediators of interferon-gamma-induced apoptosis. One of the several genes identified is DAP3, which codes for a 46 kDa...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Apoptosis Regulatory Proteins
- Caenorhabditis elegans
- Caspases
- Evolution, Molecular
- Gene Expression
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Proteins
- RNA, Antisense
- RNA-Binding Proteins
- Ribosomal Proteins
- Sequence Homology
- Signal Transduction