Molecular and cellular analysis of human immunodeficiency virus-induced apoptosis in lymphoblastoid T-cell-line-expressing wild-type and mutated CD4 receptors.

Abstract excerpt

We have previously shown that the presence of the CD4 cytoplasmic tail is critical for human immunodeficiency virus (HIV)-induced apoptosis (J. Corbeil, M. Tremblay, and D. D. Richman, J. Exp. Med. 183:39-48, 1996). We have pursued our investigation of the role of the CD4 transduction pathway in...

Topics

• Amino Acid Sequence
• Apoptosis
• CD4 Antigens
• Cell Line
• Cytoplasm
• Fas Ligand Protein
• HIV
• HIV Infections
• Humans
• Membrane Glycoproteins
• Molecular Sequence Data
• Mutation
• NF-kappa B
• Signal Transduction
• T-Lymphocytes
• Transcriptional Activation