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Article

Impact of human CD95 mutations on cell death and autoimmunity: a model.

Trends in immunology - 1 Jan 2022

Seyrek Kamil, Ivanisenko Nikita V, Wohlfromm Fabian, Espe Johannes, Lavrik Inna N

Abstract excerpt

CD95/Fas/APO-1 can trigger apoptotic as well as nonapoptotic pathways in immune cells. CD95 signaling in humans can be inhibited by several mechanisms, including mutations in the gene encoding CD95. CD95 mutations lead to autoimmune disorders, such as autoimmune lymphoproliferative syndrome (ALPS). Gaining further insight into the reported mutations of CD95 and resulting alterations of its signaling networks may...

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PMID: 34872845
DOI: 10.1016/j.it.2021.11.006

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