Article
The adenovirus E3/10.4K-14.5K proteins down-modulate the apoptosis receptor Fas/Apo-1 by inducing its internalization.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Elsing A, Burgert H G
Abstract excerpt
Adenoviruses (Ads) have evolved multiple mechanisms to evade the host immune response. Several of the immunomodulatory Ad proteins are encoded in early transcription unit 3 (E3). The E3/19K protein interferes with antigen presentation and T cell recognition, whereas the E3/10.4K, 14.5K, and 14.7K...
Topics
- Adenovirus E3 Proteins
- Adenoviruses, Human
- Amino Acid Sequence
- Apoptosis
- Base Sequence
- CD40 Antigens
- Cell Line
- Cell Membrane
- DNA Primers
- Down-Regulation
- Genes, Viral
- HeLa Cells
- Humans
- Mutation
- Open Reading Frames
- Transfection
- Virulence
- fas Receptor