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Article

Differential TRAF3 utilization by a variant human CD40 receptor with enhanced signaling.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2010

Peters Anna L, Bishop Gail A

Abstract excerpt

CD40 is required for T cell-dependent humoral immunity, but it can also contribute to the pathogenesis of autoimmunity and B cell malignancy. The TNFR-associated factor (TRAF)2 and TRAF6 adaptor proteins are positive regulators of CD40 signaling required to activate downstream kinase cascades and transcription factors. In contrast, TRAF3 can serve as a negative regulator of CD40 signaling, and CD40 signals are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21041727
DOI: 10.4049/jimmunol.1000135
PMCID: PMC3040440

Genes

TRAF3
TRAF5
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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