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Article

Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.

Carcinogenesis - 1 Feb 1999

Humbert O, Fiumicino S, Aquilina G, Branch P, Oda S, Zijno A, Karran P, Bignami M

Abstract excerpt

The long-patch mismatch repair pathway contributes to the cytotoxic effect of methylating agents and loss of this pathway confers tolerance to DNA methylation damage. Two methylation-tolerant mouse cell lines were identified and were shown to be defective in the MSH2 protein by in vitro mismatch repair assay. A normal copy of the human MSH2 gene, introduced by transfer of human chromosome 2, reversed the...

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Share to Alkylating Agents
Share to Base Pair Mismatch
Share to Chromosomes, Human, Pair 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Melanoma, Experimental

Share to Methylnitronitrosoguanidine

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Share to MutS Homolog 2 Protein

Source

Identifiers

PMID: 10069455
DOI: 10.1093/carcin/20.2.205

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.PMID 10069455Read ↗

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DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lymphomagenesis.Semantic proximity Read ↗

Biallelic mutation of MSH2 in primary human cells is associated with sensitivity to irradiation and altered RAD51 foci kinetics.Semantic proximity Read ↗

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.Semantic proximity Read ↗

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Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT.Semantic proximity Read ↗

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