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Article

A mutation in the MSH5 gene results in alkylation tolerance.

Cancer research - 1 Jul 1997

Bawa S, Xiao W

Abstract excerpt

DNA methylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) are potent carcinogens; their carcinogenic effect is mainly due to the effect of production of O6-methylguanine (O6 MeG) on DNA. O6 MeG is not only mutagenic but also toxic to the cell because Mer-/Mex- cells unable to remove O6 MeG are very sensitive to killing by MNNG. It has been proposed that repeated futile mismatch correction of O6...

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Source

Identifiers

PMID: 9205082

Genes

MSH5
MLH1
MSH2
MSH3
MSH6
PMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutation in the MSH5 gene results in alkylation tolerance.PMID 9205082Read ↗

A single amino acid substitution in MSH5 results in DNA alkylation tolerance.Semantic proximity Read ↗

DNA mismatch repair mutants do not increase N-methyl-N'-nitro-N-nitrosoguanidine tolerance in O6-methylguanine DNA methyltransferase-deficient yeast cells.Semantic proximity Read ↗

Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch RepairSemantic proximity Read ↗

Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2 and MSH2 genes.Semantic proximity Read ↗

DNA mismatch repair and mutation avoidance pathways.Semantic proximity Read ↗

Analysis of yeast pms1, msh2, and mlh1 mutators points to differences in mismatch correction efficiencies between prokaryotic and eukaryotic cells.Semantic proximity Read ↗

MSH2 is essential for the preservation of genome integrity and prevents homeologous recombination in the moss Physcomitrella patens.Semantic proximity Read ↗

Nuclear Translocation of Mismatch Repair Proteins MSH2 and MSH6 as a Response of Cells to Alkylating AgentsSemantic proximity Read ↗

Genome-wide contributions of the MutSα- and MutSβ-dependent DNA mismatch repair pathways to the maintenance of genetic stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognition.Semantic proximity Read ↗

Analysis of yeast MSH2-MSH6 suggests that the initiation of mismatch repair can be separated into discrete steps.Semantic proximity Read ↗

The yeast gene MSH3 defines a new class of eukaryotic MutS homologues.Semantic proximity Read ↗

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