A mutation in the MSH5 gene results in alkylation tolerance.

Article

A mutation in the MSH5 gene results in alkylation tolerance.

Cancer research - 1 Jul 1997

Bawa S, Xiao W

Abstract excerpt

DNA methylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) are potent carcinogens; their carcinogenic effect is mainly due to the effect of production of O6-methylguanine (O6 MeG) on DNA. O6 MeG is not only mutagenic but also toxic to the cell because Mer-/Mex- cells unable to rem...

Topics

Alkylation
DNA Repair
DNA-Binding Proteins
Drug Tolerance
Fungal Proteins
Methylnitronitrosoguanidine
Methyltransferases
Mutation
Saccharomyces cerevisiae Proteins
Yeasts

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