Article
The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.
Neuron - 1 Jun 1998
García-Añoveros J, García J A, Liu J D, Corey D P
Abstract excerpt
Nematode degenerins have been implicated in touch sensitivity and other forms of mechanosensation. Certain mutations in several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations in the muscle degenerin gene unc-105 cause hypercontraction. Here, we confirm...
Topics
- Amiloride
- Animals
- Apoptosis
- Caenorhabditis elegans Proteins
- Cell Size
- Cell Survival
- Cells, Cultured
- Diuretics
- Gene Expression
- Helminth Proteins
- Humans
- Ion Channel Gating
- Ion Channels
- Kidney
- Microscopy, Electron
- Mutation
- Oocytes
- Patch-Clamp Techniques