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Article

Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain.

Current biology : CB - 1 Apr 1995

García-Añoveros J, Ma C, Chalfie M

Abstract excerpt

BACKGROUND: Rare, dominant mutations in the degenerin genes of Caenorhabditis elegans (deg-1, mec-4 and mec-10) cause neuronal degeneration. The extensive sequence similarity between degenerins and mammalian genes that encode subunits of the amiloride-sensitive sodium channel from kidney, colon and lung suggests that the C. elegans degenerins form ion channels. As mec-4 and mec-10 are needed for the reception of...

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PMID: 7627559
DOI: 10.1016/s0960-9822(95)00085-6

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Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain.PMID 7627559Read ↗

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