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Article

Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain.

Current biology : CB - 1 Apr 1995

García-Añoveros J, Ma C, Chalfie M

Abstract excerpt

BACKGROUND: Rare, dominant mutations in the degenerin genes of Caenorhabditis elegans (deg-1, mec-4 and mec-10) cause neuronal degeneration. The extensive sequence similarity between degenerins and mammalian genes that encode subunits of the amiloride-sensitive sodium channel from kidney, colon and lung suggests that the C. elegans degenerins form ion channels. As mec-4 and mec-10 are needed for the reception of...

Topics

Amino Acid Sequence
Animals
Base Sequence
Caenorhabditis elegans
Caenorhabditis elegans Proteins
DNA, Helminth
Helminth Proteins
Membrane Proteins
Molecular Sequence Data
Mutation
Nerve Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sodium Channels

Source

Identifiers

PMID: 7627559
DOI: 10.1016/s0960-9822(95)00085-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7627559-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain.PMID 7627559Read ↗

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