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Article

A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans.

Nature - 3 Feb 1994

Hong K, Driscoll M

Abstract excerpt

Aberrant ion channel activity plays a causative role in several human disorders. Inappropriately regulated channel activity also appears to be the basis for neurodegeneration induced by dominant mutations of Caenorhabditis elegans mec-4 (mec-4(d)), a member of the degenerin gene family postulated to encode a subunit of a mechanosensory channel. The degenerin gene family has been defined by two C. elegans genes,...

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PMID: 8107806
DOI: 10.1038/367470a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans.PMID 8107806Read ↗

Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain.Semantic proximity Read ↗

The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration.Semantic proximity Read ↗

MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans.Semantic proximity Read ↗

Temperature-sensitive mutant of the Caenorhabditis elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface maintenance.Semantic proximity Read ↗

Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations.Semantic proximity Read ↗

MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation.Semantic proximity Read ↗

Functional features of the "finger" domain of the DEG/ENaC channels MEC-4 and UNC-8.Semantic proximity Read ↗

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Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.Semantic proximity Read ↗

Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade.Semantic proximity Read ↗

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