A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans.

doi:10.1038/367470a0

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Article

A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans.

Nature - 3 Feb 1994

Hong K, Driscoll M

Abstract excerpt

Aberrant ion channel activity plays a causative role in several human disorders. Inappropriately regulated channel activity also appears to be the basis for neurodegeneration induced by dominant mutations of Caenorhabditis elegans mec-4 (mec-4(d)), a member of the degenerin gene family postulated to encode a subunit of a mechanosensory channel. The degenerin gene family has been defined by two C. elegans genes,...

Topics

Alleles
Amino Acid Sequence
Amino Acids
Animals
Animals, Genetically Modified
Base Sequence
Binding Sites
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Conserved Sequence
DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Helminth Proteins

Mechanoreceptors

Membrane Proteins

Molecular Sequence Data

Mutagenesis, Site-Directed

Nerve Degeneration

Neural Conduction

Source

Open in PubMed

Identifiers

PMID: 8107806
DOI: 10.1038/367470a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8107806-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans.PMID 8107806Read ↗

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