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Article

Inhibition of human immunodeficiency virus type 1 virion entry by dominant-negative Hck.

Journal of virology - 1 Jul 1998

Tokunaga K, Kiyokawa E, Nakaya M, Otsuka N, Kojima A, Kurata T, Matsuda M

Abstract excerpt

To study the role of Src family tyrosine kinases in infection with human immunodeficiency virus type 1 (HIV-1), we constructed an Hck mutant, HckN, that hinders signaling from wild-type Hck. HIV-1 produced in HckN-expressing cells was significantly less infectious to HeLa-CD4-LTR-beta-gal (MAGI) cells than HIV-1 produced in mock-transfected cells. The inhibitory effect of HckN was compensated for by the...

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Identifiers

PMID: 9621101
DOI: 10.1128/JVI.72.7.6257-6259.1998
PMCID: PMC110455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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