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Article

Use of a human immunodeficiency virus type 1 Rev mutant without nucleolar dysfunction as a candidate for potential AIDS therapy.

Journal of virology - 1 Mar 1995

Furuta R A, Kubota S, Maki M, Miyazaki Y, Hattori T, Hatanaka M

Abstract excerpt

Applications of transdominant mutants of human immunodeficiency virus type 1 (HIV-1) regulatory proteins, especially Rev mutant, have been attempted for gene therapy against AIDS, because the Rev protein is essential for viral replication. We have previously reported that a mutant Rev protein (dRev) lacking its nucleolar targeting signal remained out of nuclei in expressed cells and strongly inhibited the...

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Identifiers

PMID: 7853493
DOI: 10.1128/JVI.69.3.1591-1599.1995
PMCID: PMC188754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Use of a human immunodeficiency virus type 1 Rev mutant without nucleolar dysfunction as a candidate for potential AIDS therapy.PMID 7853493Read ↗

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Nuclear export of the human immunodeficiency virus type 1 nucleocytoplasmic shuttle protein Rev is mediated by its activation domain and is blocked by transdominant negative mutants.Semantic proximity Read ↗

Cytotoxic activity of rev protein of human immunodeficiency virus type 1 by nucleolar dysfunction.Semantic proximity Read ↗

[Gene therapy of AIDS by a Rev mutant without nucleolar dysfunction].Semantic proximity Read ↗

A trans-dominant negative HIV type 1 Rev with intact domains of NLS/NOS and NES.Semantic proximity Read ↗

Analysis of trans-dominant mutants of the HIV type 1 Rev protein for their ability to inhibit Rev function, HIV type 1 replication, and their use as anti-HIV gene therapeutics.Semantic proximity Read ↗

The nuclear function of the nuclear diffusion inhibitory signal of human immunodeficiency virus type 1: critical roles in dominant nuclear localization and intracellular stability.Semantic proximity Read ↗

Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization.Semantic proximity Read ↗

Modified human immunodeficiency virus-based lentiviral vectors display decreased sensitivity to trans-dominant Rev.Semantic proximity Read ↗

Regulated expression of a dominant negative form of Rev improves resistance to HIV replication in T cells.Semantic proximity Read ↗

Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm.Semantic proximity Read ↗

trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes.Semantic proximity Read ↗

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