Use of a human immunodeficiency virus type 1 Rev mutant without nucleolar dysfunction as a candidate for potential AIDS therapy.

doi:10.1128/JVI.69.3.1591-1599.1995

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Article

Use of a human immunodeficiency virus type 1 Rev mutant without nucleolar dysfunction as a candidate for potential AIDS therapy.

Journal of virology - 1 Mar 1995

Furuta R A, Kubota S, Maki M, Miyazaki Y, Hattori T, Hatanaka M

Abstract excerpt

Applications of transdominant mutants of human immunodeficiency virus type 1 (HIV-1) regulatory proteins, especially Rev mutant, have been attempted for gene therapy against AIDS, because the Rev protein is essential for viral replication. We have previously reported that a mutant Rev protein (dRev) lacking its nucleolar targeting signal remained out of nuclei in expressed cells and strongly inhibited the...

Topics

Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Base Sequence
Cell Line
Cell Nucleolus
DNA Primers
Gene Expression Regulation, Viral
Genes, Dominant
Genes, rev
Genetic Therapy
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HeLa Cells

Humans

Molecular Sequence Data

Mutation

RNA, Viral

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 7853493
DOI: 10.1128/JVI.69.3.1591-1599.1995
PMCID: PMC188754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7853493-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Use of a human immunodeficiency virus type 1 Rev mutant without nucleolar dysfunction as a candidate for potential AIDS therapy.PMID 7853493Read ↗

Nucleocytoplasmic transport of the Rev protein of human immunodeficiency virus type 1 is dependent on the activation domain of the protein.Semantic proximity Read ↗

Nuclear export of the human immunodeficiency virus type 1 nucleocytoplasmic shuttle protein Rev is mediated by its activation domain and is blocked by transdominant negative mutants.Semantic proximity Read ↗

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[Gene therapy of AIDS by a Rev mutant without nucleolar dysfunction].Semantic proximity Read ↗

A trans-dominant negative HIV type 1 Rev with intact domains of NLS/NOS and NES.Semantic proximity Read ↗

Analysis of trans-dominant mutants of the HIV type 1 Rev protein for their ability to inhibit Rev function, HIV type 1 replication, and their use as anti-HIV gene therapeutics.Semantic proximity Read ↗

The nuclear function of the nuclear diffusion inhibitory signal of human immunodeficiency virus type 1: critical roles in dominant nuclear localization and intracellular stability.Semantic proximity Read ↗

Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization.Semantic proximity Read ↗

Modified human immunodeficiency virus-based lentiviral vectors display decreased sensitivity to trans-dominant Rev.Semantic proximity Read ↗

Regulated expression of a dominant negative form of Rev improves resistance to HIV replication in T cells.Semantic proximity Read ↗

Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm.Semantic proximity Read ↗

trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes.Semantic proximity Read ↗

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