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Article

Hck SH3 domain-dependent abrogation of Nef-induced class 1 MHC down-regulation.

European journal of immunology - 1 Aug 2001

Chang A H, O'Shaughnessy M V, Jirik F R

Abstract excerpt

The ability of specific virally encoded proteins to down-regulate MHC class I molecules may enable infected cells to elude killing by CTL. In the case of HIV-1, Nef appears to be responsible for this effect. Thus, interfering with Nef-induced MHC class I down-regulation would be a strategy for increasing HIV-1-specific CTL activity, particularly towards long-lived T cell populations such as memory T cells that...

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Identifiers

PMID: 11500821
DOI: 10.1002/1521-4141(200108)31:8<2382::aid-immu2382>3.0.co;2-k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hck SH3 domain-dependent abrogation of Nef-induced class 1 MHC down-regulation.PMID 11500821Read ↗

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