Article
Upregulation of P-glycoprotein in rat hepatoma rho(o) cells: implications for drug-DNA interactions.
Journal of cellular biochemistry - 15 Jun 1998
Pillay V, Martinus R D, Hill J S, Phillips D R
Abstract excerpt
Rat hepatoma cells lacking mitochondrial DNA (rho(o) cells) were used as a model system to examine the possible roles of mitochondrial DNA as a target for the DNA-acting anticancer drug Adriamycin (doxorubicin). The rho(o) cells were 45-fold less sensitive to Adriamycin than the parental rho+ cel...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antibiotics, Antineoplastic
- Cyclosporins
- DNA, Mitochondrial
- Dose-Response Relationship, Drug
- Doxorubicin
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Gene Expression Regulation, Neoplastic
- Liver Neoplasms, Experimental
- Phenotype
- RNA, Messenger
- RNA, Neoplasm
- Rats
- Tumor Cells, Cultured