Article
Components of intrinsic drug resistance in the rat hepatoma.
Biochemical pharmacology - 22 Jan 1992
Ellis A L, Munger C E, Bunch R T, Woods K E, Randolph J K, Boise L, Swerdlow P S, Zwelling L A, Hinds M, Yanovich S
Abstract excerpt
A carcinogen-transformed rat hepatoma cell line (Reuber H-35) was utilized as a model system for investigation of the biochemical factors which may limit the effectiveness of chemotherapy in intrinsically resistant tumors such as hepatocellular carcinoma. Northern blotting demonstrated expression of mRNA coding for the P-170 membrane-glycoprotein associated with the multi-drug resistance phenotype, while Western...
Topics
- Animals
- Antineoplastic Agents
- Binding Sites
- Blotting, Northern
- Blotting, Western
- Cell Division
- Cell Fractionation
- Cell Line
- DNA Damage
- Drug Resistance
- Glutathione