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Resistance of Mitochondrial DNA-depleted Cells against Cell Death

1 Feb 2004

Abstract excerpt

We have shown that mitochondrial DNA-depleted (rho(0)) SK-Hep1 hepatoma cells are resistant to apoptosis, contrary to previous papers reporting normal apoptotic susceptibility of rho(0) cells. We studied the changes of gene expression in SK-Hep1 rho(0) cells. DNA chip analysis showed that MnSOD expression was profoundly increased in rho(0) cells. O(2)(.) contents increased during rho(0) cell derivation but became...

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PMID: 14660625
DOI: 10.1074/jbc.m307677200

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