Transactivation of the human MDR1 gene by hepatitis B virus X gene product.

doi:10.1016/s0168-8278(98)80113-x

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Article

Transactivation of the human MDR1 gene by hepatitis B virus X gene product.

Journal of hepatology - 1 Dec 1998

Doong S L, Lin M H, Tsai M M, Li T R, Chuang S E, Cheng A L

Abstract excerpt

BACKGROUND/AIMS: Persistent hepatitis B virus (HBV) infection may cause hepatocellular carcinoma. Patients with hepatocellular carcinoma are characterized by nonresponsiveness to chemotherapeutic agents. While many studies have been devoted to understanding the hepatocarcinogenesis mechanism of H...

Topics

Cloning, Molecular
Gene Expression Regulation, Viral
Genes, MDR
Hepatitis B virus
Humans
Phenotype
Tetrazolium Salts
Transcription Factors
Transcriptional Activation

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