Article
Overexpression of the multidrug resistance-associated protein (MRP) gene in vincristine but not doxorubicin-selected multidrug-resistant murine erythroleukemia cells.
Cancer research - 1 Nov 1994
Slapak C A, Fracasso P M, Martell R L, Toppmeyer D L, Lecerf J M, Levy S B
Abstract excerpt
Multidrug-resistant sublines of the murine erythroleukemia cell line PC4 were sequentially selected in increasing vincristine concentrations (5-160 ng/ml). The low- and intermediate-level resistant cell lines, selected in < or = 40 ng/ml of vincristine, demonstrated resistance to Vinca alkaloids...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Base Sequence
- Doxorubicin
- Drug Resistance
- Leukemia, Erythroblastic, Acute
- Mice
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction
- Tumor Cells, Cultured
- Vincristine