Article
PAX genes.
Current opinion in genetics & development - 1 Jun 1994
Strachan T, Read A P
Abstract excerpt
PAX genes are developmental control genes that encode transcription factors containing a DNA-binding paired domain. Mutations in three of the nine mouse genes (Pax1, Pax3 and Pax6) and two of the nine human genes (PAX3 and PAX6) are known to cause developmental defects. These defects are caused by loss-of-function alleles; pathogenesis occurs as a result of a half dosage of the PAX gene product in particular...
Topics
- Animals
- Base Sequence
- Biological Evolution
- Consensus Sequence
- DNA
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- Genes
- Humans
- Mice
- Molecular Sequence Data
- Mutation