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Article

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2001

Ehrenstein M R, Rada C, Jones A M, Milstein C, Neuberger M S

Abstract excerpt

Isotype switching involves a region-specific, nonhomologous recombinational deletion that has been suggested to occur by nonhomologous joining of broken DNA ends. Here, we find increased donor/acceptor homology at switch junctions from PMS2-deficient mice and propose that class switching can occur by microhomology-mediated end-joining. Interestingly, although isotype switching and somatic hypermutation show many...

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Share to Adenosine Triphosphatases
Share to Base Pair Mismatch

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to DNA Repair Enzymes

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Share to Sequence Homology, Nucleic Acid

Source

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Identifiers

PMID: 11717399
DOI: 10.1073/pnas.241525998
PMCID: PMC64720

Genes

PMS2
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.PMID 11717399Read ↗

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