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Article

Mismatch repair co-opted by hypermutation.

Science (New York, N.Y.) - 20 Feb 1998

Cascalho M, Wong J, Steinberg C, Wabl M

Abstract excerpt

Mice homozygous for a disrupted allele of the mismatch repair gene Pms2 have a mutator phenotype. When this allele is crossed into quasi-monoclonal (QM) mice, which have a very limited B cell repertoire, homozygotes have fewer somatic mutations at the immunoglobulin heavy chain and lambda chain loci than do heterozygotes or wild-type QM mice. That is, mismatch repair seems to contribute to somatic hypermutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9469811
DOI: 10.1126/science.279.5354.1207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mismatch repair co-opted by hypermutation.PMID 9469811Read ↗

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A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.Semantic proximity Read ↗

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process.Semantic proximity Read ↗

Altered spectra of hypermutation in DNA repair-deficient mice.Semantic proximity Read ↗

Frequency and types of spontaneous Hprt lymphocyte mutations in Pms2-deficient mice.Semantic proximity Read ↗

DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouseSemantic proximity Read ↗

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein.Semantic proximity Read ↗

PMS2-deficiency diminishes hypermutation of a lambda1 transgene in young but not older mice.Semantic proximity Read ↗

Maternal effect for DNA mismatch repair in the mouse.Semantic proximity Read ↗

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Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.Semantic proximity Read ↗

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