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Article

Deposition-related sites K5/K12 in histone H4 are not required for nucleosome deposition in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 1998

Ma X J, Wu J, Altheim B A, Schultz M C, Grunstein M

Abstract excerpt

Histone H4 can be acetylated at N-terminal lysines K5, K8, K12, and K16, but newly synthesized H4 is diacetylated at K5/K12 in diverse organisms. This pattern is widely thought to be important for histone deposition onto replicating DNA. To investigate the importance of K5/K12 we have mutagenized these lysines in yeast and assayed for nucleosome assembly. Assaying was done in the absence of the histone H3 N...

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Identifiers

PMID: 9618474
DOI: 10.1073/pnas.95.12.6693
PMCID: PMC22601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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