Article
A novel histone H4 mutant defective in nuclear division and mitotic chromosome transmission.
Molecular and cellular biology - 1 Mar 1996
Smith M M, Yang P, Santisteban M S, Boone P W, Goldstein A T, Megee P C
Abstract excerpt
The histone proteins are essential for the assembly and function of th e eukaryotic chromosome. Here we report the first isolation of a temperature-sensitive lethal histone H4 mutant defective in mitotic chromosome transmission Saccharomyces cerevisiae. The mutant requires two amino acid substitu...
Topics
- Chromatin
- Histones
- Mitosis
- Mutation
- Saccharomyces cerevisiae
- Transcription, Genetic