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Article

A novel histone H4 mutant defective in nuclear division and mitotic chromosome transmission.

Molecular and cellular biology - 1 Mar 1996

Smith M M, Yang P, Santisteban M S, Boone P W, Goldstein A T, Megee P C

Abstract excerpt

The histone proteins are essential for the assembly and function of th e eukaryotic chromosome. Here we report the first isolation of a temperature-sensitive lethal histone H4 mutant defective in mitotic chromosome transmission Saccharomyces cerevisiae. The mutant requires two amino acid substitutions in histone H4: a lethal Thr-to-Ile change at position 82, which lies within one of the DNA-binding surfaces of...

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Identifiers

PMID: 8622646
DOI: 10.1128/MCB.16.3.1017
PMCID: PMC231084

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