Article
A conserved patch near the C terminus of histone H4 is required for genome stability in budding yeast.
Molecular and cellular biology - 1 Jun 2011
Yu Yao, Srinivasan Madhusudhan, Nakanishi Shima, Leatherwood Janet, Shilatifard Ali, Sternglanz Rolf
Abstract excerpt
A screen of Saccharomyces cerevisiae histone alanine substitution mutants revealed that mutations in any of three adjacent residues, L97, Y98, or G99, near the C terminus of H4 led to a unique phenotype. The mutants grew slowly, became polyploid or aneuploid rapidly, and also lost chromosomes at a high rate, most likely because their kinetochores were not assembled properly. There was lower histone occupancy, not...
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