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Article

An evolutionarily 'young' lysine residue in histone H3 attenuates transcriptional output in Saccharomyces cerevisiae.

Genes & development - 15 Jun 2011

Hyland Edel M, Molina Henrik, Poorey Kunal, Jie Chunfa, Xie Zhi, Dai Junbiao, Qian Jiang, Bekiranov Stefan, Auble David T, Pandey Akhilesh, Boeke Jef D

Abstract excerpt

The DNA entry and exit points on the nucleosome core regulate the initial invasion of the nucleosome by factors requiring access to the underlying DNA. Here we describe in vivo consequences of eliminating a single protein-DNA interaction at this position through mutagenesis of histone H3 Lys 42 to alanine. This substitution has a dramatic effect on the Saccharomyces cerevisiae transcriptome in both the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21685365
DOI: 10.1101/gad.2050311
PMCID: PMC3127431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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