Article
Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping.
Clinical pharmacology and therapeutics - 1 Nov 1999
Streetman D S, Ellis R E, Nafziger A N, Leeder J S, Gaedigk A, Gotschall R, Kearns G L, Bertino J S
Abstract excerpt
Most dextromethorphan CYP2D6 phenotyping studies use a 30-mg dose, but data that show superiority of any particular dose are lacking. We compared metabolic ratios from six different dextromethorphan phenotyping doses to ascertain whether linearity existed over a dosage range. Forty subjects were enrolled in the study. Each subject received 0.05 mg/kg, 0.15 mg/kg, 0.3 mg/kg, 30 mg, 0.8 mg/kg, and 1.2 mg/kg...
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