Article
Salivary analysis for determination of dextromethorphan metabolic phenotype.
Clinical pharmacology and therapeutics - 1 Apr 1991
Hou Z Y, Pickle L W, Meyer P S, Woosley R L
Abstract excerpt
Debrisoquin oxidative phenotype is a determinant of pharmacologic response for many drugs. Poor and extensive metabolizers can be identified by the dextromethorphan metabolic ratio (dextromethorphan/dextrorphan). We developed and tested a method to determine debrisoquin phenotype on the basis of the metabolic ratio in saliva. Each of 62 normal volunteers was given a 50 mg capsule of dextromethorphan hydrobromide...
Topics
- Administration, Oral
- Adult
- Chromatography, High Pressure Liquid
- Dextromethorphan
- Dextrorphan
- Female
- Humans
- Male
- Middle Aged
- Phenotype
- Racial Groups
- Saliva